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Synthesis of C -Propargylic Esters of N-Protected Amino Acids and Peptides

✍ Scribed by Bew, Sean P.; Hiatt-Gipson, Glyn D.


Book ID
126257843
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
740 KB
Volume
75
Category
Article
ISSN
0022-3263

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Synthesis and reactions of esters of N-h
✍ G. H. L. Nefkens; G. I. Tesser; R. J. F. Nivard 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 313 KB

## Abstract Esters can be prepared from __N__‐hydroxyphthalimide and __N__‐carbobenzoxy‐ or __N__‐phthaloyl‐amino acids using dicyclohexylcarbodi‐imide as condensing agent. The compounds are suitable for the stepwise synthesis of peptides without racemization. With methanol the __N__‐hydroxyphthali