ChemInform Abstract: Synthesis of C-Propargylic Esters of N-Protected Amino Acids and Peptides.
β Scribed by Sean P. Bew; Glyn D. Hiatt-Gipson
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 23 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Abstract
The method works well for Bocβ and Cbzβprotected substrates.
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Papain catalyzed synthesis of glyceryl esters of BOC(Z)-protected amino acids and peptides was performed at 40-50Β°C in a 50 molar excess of glycerol. Equilibrium was achieved in 6-7 h. The maximal yield of esters (50-70%) was obtained at 10% of water and pH 3.2-3.4. A lower water concentration resul
Synthesis of N,N'-Carbonyl-bis-amino Acids and N,N'-Carbonyl-bispeptides. -A new and convenient method for the synthesis of dimeric peptides with a carbonyl group as linkage between the N-terminal amino groups is elaborated. -(IZDEBSKI,