Solution NMR structures of the polyene macrolide antibiotic filipin III
β Scribed by Laurent Volpon; Jean-Marc Lancelin
- Book ID
- 117102100
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 124 KB
- Volume
- 478
- Category
- Article
- ISSN
- 0014-5793
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Candidin,the heptaene macrolide antifungal antibiotic from Streptornvces viridoflavus';was recognised to be a mixture of three active principles all belonging to the %onarotnatic" subgroup of heptaenes 2,3 .The name candidin was retained for the main component of the antibiotic complex while the two
The enantioselective construction of the iterative polyacetate unit 3 in filipin III has been accomplished, essentially by an aldol strategy based on chiral oxazaborolidinone-promoted asymmetric aldol reactions.
Nystatin,the most commonly used clinical polyene macrolide antifungal antibiotic from Streotomyces noursei', and first discovered member of this group of natural products,has rather long record of chemical studies.It was generally characte-