The complete structure of the polyene macrolide antibiotic nystatin A1
✍ Scribed by E. Borowski; J. Zieliński; L. Falkowski; T. Zimiński; J. Golik; P. Kołodziejczyk; E. Jereczek; M. Gdulewicz; Yu. Shenin; T. Kotienko
- Publisher
- Elsevier Science
- Year
- 1971
- Tongue
- French
- Weight
- 300 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Nystatin,the most commonly used clinical polyene macrolide antifungal antibiotic from Streotomyces noursei', and first discovered member of this group of natural products,has rather long record of chemical studies.It was generally characte-
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Candidin,the heptaene macrolide antifungal antibiotic from Streptornvces viridoflavus';was recognised to be a mixture of three active principles all belonging to the %onarotnatic" subgroup of heptaenes 2,3 .The name candidin was retained for the main component of the antibiotic complex while the two
Complete mass spectra of the pertrimethylsilylated derivatives of three high molecular weight polyene macrolide antibiotics are reported for the first time. The fragmentation pathways which are proposed have been corroborated by the stable isotope derivatives d,-TMS and d,-acetyl. Accurate mass meas