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The structure of the aglycone of the macrolide antibiotic nystatin

✍ Scribed by D.G. Manwaring; R.W. Rickards; B.T. Golding

Publisher
Elsevier Science
Year
1969
Tongue
French
Weight
224 KB
Volume
10
Category
Article
ISSN
0040-4039

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✦ Synopsis

Ikeda, Suzuki and Djerassi' extended previous joint work 2,3 on nystatin, the chemotherapeutically-important antifungal agent4 from Streptomyces noursei', and proposed constitution (I; R = OH) for nystatinolide, its hypothetical aglycone. This structure (I; R = OH) corresponds to C41H64015' and with the attachment of mycosamine6 leads to the molecular formula C47H,SN018

for nystatin itself.

We present here evidence that nystatin is correctly formulated as C47H75N017p and that nystatinolide has the constitution (I; R = H).

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