## Abstract The immunobiology of an antigenic methylcholanthrene‐induced sarcoma (MC‐D) of inbred strain 13 guinea pigs has been investigated. The induction of concomitant immunity by growing MC‐D tumors was indicated by the suppression of small tumor inocula in the presence of a large tumor cell d
Soluble tumor-specific transplantation antigens from methylcholanthrens induced guinea pig sarcomas
✍ Scribed by E. Carmack Holmes; Barry D. Kahan; Donald L. Morton
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 965 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Methylcholanthrene‐induced sarcomas of BALB/c mice express unique tumor specific transplantation antigens (TSTA), and weaker, common TSTA. Antigens of endogenous murine leukemia virus (MuLV) expressed by some of these tumors cannot completely account for these common TSTA. However, MuLV
## Abstract Sarcomas induced by the chemical carcinogen 3‐methyl‐cholanthrene (MC) in pedigreed BALB/c strain mice were studied for the existence and characteristics of tumorspecific antigens that induce protective immune defenses in syngeneic mice (TATA). It was found that each of the neoplasms ex
## Abstract Tumor‐specific transplantation antigens (TSTA) expressed by cells from transplantable lines of 3‐methyl‐cholanthrene‐induced BALB/c sarcomas were maintained over a 26‐week culture period, which represented 2–32 passages __in vitro__. Cells from __in vitro__‐passaged sarcomas were immuno
The DNA of 22 fibrosarcomas, newly induced in 0ALWc mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonuc
## Abstract The subcellular distribution of the tumor‐associated transplantation antigens (TATAs) of two highly immunogenic methylcholanthrene‐induced sarcomas, Meth A and CI‐4, were compared. Most of the TATA of CI‐4 was found in the soluble fraction (cytosol) of the cell while the TATA from Meth