𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Generation of crossreacting tumor antigens in ascitic derivatives from murine methylcholanthrene-induced sarcomas

✍ Scribed by Lloyd W. Law

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
569 KB
Volume
33
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Sarcomas induced by the chemical carcinogen 3‐methyl‐cholanthrene (MC) in pedigreed BALB/c strain mice were studied for the existence and characteristics of tumorspecific antigens that induce protective immune defenses in syngeneic mice (TATA). It was found that each of the neoplasms expressed a unique immunogenicity that was stable and heritable over a period of 125 transfers in vivo. Common or crossreacting TATA were not observed. When converted to an ascitic form, two of these sarcomas, CII‐7 and CII‐10, were found to be crossreactive, presumably sharing TATA with each other and with the MC‐induced sarcoma Meth A. Two other neoplasms converted to the ascitic form, however, retained their unique TATA. Although the precise nature of unique and crossreacting TATA is not known, it is hoped that recent investigations in the purification of TATA of chemically induced neoplasms will shed light on the mechanisms responsible for the diversity of tumor‐specific antigens.

📜 SIMILAR VOLUMES

Activation of ras oncogenes and expressi
Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas
✍ Giusi Carbone; Maria Grazia Borrello; Alessandra Molla; Maria Grazia Rizzetti; M 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 French ⚖ 710 KB

The DNA of 22 fibrosarcomas, newly induced in 0ALWc mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonuc

Detection of private and common tumor-as
Detection of private and common tumor-associated antigens in murine sarcomas induced by different chemical carcinogens
✍ D. Fritze; D. H. Kern; J. A. Humme; C. R. Drogemuller; Dr. Y. H. Pilch 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 758 KB

## Abstract Two fibrosarcomas of similar histological type, induced in C3Hf mice by either methylcholanthrene or 3,4‐benz(a)pyrene, were shown to have individually unique tumor‐rejection antigens in classical transplantation‐type experiments. By contrast, sera of autochthonous mice, which resisted

Changes in tumor-specific antigen expres
Changes in tumor-specific antigen expression during passage in vitro and in vivo of newly derived methylcholanthrene-induced sarcomas of BALB/c mice
✍ Lloyd W. Law 📂 Article 📅 1980 🏛 John Wiley and Sons 🌐 French ⚖ 788 KB

## Abstract The characteristics of tumor antigens of the transplantation type, TATA, were studied in a series of methylcholanthrene‐induced sarcomas in pedigreed BALB/cAN mice. Each of the six sarcomas exhibited unique TATA when assayed for tumor rejection in syngeneic hosts. In three instances, ho

Actinomycin-D-resistant in vitro mouse c
Actinomycin-D-resistant in vitro mouse cell line derived from a methylcholanthrene-induced sarcoma: Decrease of malignancy and antigenic characteristics
✍ J. Belehradek Jr.; J. L. Biedler; M. Thonier; G. Barski 📂 Article 📅 1974 🏛 John Wiley and Sons 🌐 French ⚖ 761 KB

## Abstract The tumorigenic EPO clonal cell line, derived from a methylcholanthrene‐induced murine sarcoma, was exposed to increasing concentrations of actinomycin D and gave rise to a subline, resistant to 0.02 μg of actinomycin D per ml of medium, which was designated EPO/ADj. Drug resistance was

Biochemical characterization and biologi
Biochemical characterization and biologic activities of 82-and 86-kDa tumor antigens isolated from a methylcholanthrene-induced sarcoma, CII-7
✍ Garrett C. Dubois; Lloyd W. Law 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 French ⚖ 853 KB

Two tumor-specific antigens, with molecular weights of approximately 82 and 86 kDa, have been isolated and purified to apparent homogeneity from the methylcholanthrene-induced sarcoma, Cll-7. The method of purification used was essentially that previously employed for the isolation of the 82-and 86-

Dissociation of anti-tumor immune respon
Dissociation of anti-tumor immune responses in rats immunized with solubilized tumor-associated antigens from a methylcholanthrene-induced fibrosarcoma
✍ Akio Minami; Yutaka Mizushima; Noritoshi Takeichi; Masuo Hosokawa; Hiroshi Kobay 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 French ⚖ 752 KB

## Abstract Soluble tumor antigens were prepared from chemically‐induced rat fibrosarcoma KMT‐17 cells by various methods [Na‐deoxycholate (DOC), 3 M‐KCI extraction, and crude membrane preparations by mechanical disruption]. Soluble tumor antigens prepared by DOC extraction (DOC‐STA) could be detec