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Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas

✍ Scribed by Giusi Carbone; Maria Grazia Borrello; Alessandra Molla; Maria Grazia Rizzetti; Marco A. Pierotti; Giuseppe Della Porta; Giorgio Parmiani

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
710 KB
Volume
47
Category
Article
ISSN
0020-7136

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✦ Synopsis

The DNA of 22 fibrosarcomas, newly induced in 0ALWc mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively.

No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridization performed on the DNA of the 22 sarcomas revealed 5 cases of K-ras mutation at codon 12, 3 at codon 13 and I at both codons. One case of K13 ' p 4 0.005 as compared with TSTA-tumors.

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