Detection of private and common tumor-associated antigens in murine sarcomas induced by different chemical carcinogens

✍ Scribed by D. Fritze; D. H. Kern; J. A. Humme; C. R. Drogemuller; Dr. Y. H. Pilch

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: French
• Weight: 758 KB
• Volume: 17
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910170118

✦ Synopsis

Abstract

Two fibrosarcomas of similar histological type, induced in C3Hf mice by either methylcholanthrene or 3,4‐benz(a)pyrene, were shown to have individually unique tumor‐rejection antigens in classical transplantation‐type experiments. By contrast, sera of autochthonous mice, which resisted only transplants of the immunizing sarcoma, were found to contain complement‐dependent cytotoxic antibodies, specific for both sarcomas, in vitro. The existence of individually unique as well as common tumor‐associated antigens in chemically‐induced murine sarcomas is suggested. The private. “tumor transplantation‐type” antigens elicited tumor rejection responses in vivo. The common tumor‐associated antigens, although immunogenic in autochthnous hosts, inducing the production of tumor‐specific antibodies, failed to induce transplantation crossresistance in vivo. This study supports the contention that, in carcinogen‐induced murine tumors, and perhaps in human neoplasms as well, the evaluation of humoral (and cell‐mediated) immune responses in vitro may not reflect tumor rejection‐type immune responses in vivo.