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Detection of a tumor-associated glycoprotein antigen in serum and urine of melanoma patients by murine monoclonal antibody (AD1-40F4) in enzyme immunoassay

✍ Scribed by David M. Euhus; Ph.D. Rishab K. Gupta; Donald L. Morton

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 620 KB
Volume: 3
Category: Article
ISSN: 0887-8013
DOI: 10.1002/jcla.1860030309

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✦ Synopsis

The urine of 68% of melanoma patients contains a high molecular weight glycoprotein which is expressed by melanoma cells and reacts with autologous antibody. Since high levels of this antigen in urine correlate with disease recurrence in surgically treated melanoma patients, it has been termed urinary tumor-associated antigen (U-TAA). We report the development of a murine monoclonal IgM antibody (AD1-40F4), which is specific for U-TAA. AD1 -4OF4 showed the same pattern of reactivity as the allo-antibodies previously used for the detection of U-TAA. The

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