Genetics of murine sarcoma virus (msv)—induced tumors in akr mice: Evidence that late progressing and early regressing tumors are controlled by different genes
✍ Scribed by A. Colombatti; L. Chieco-Bianchi; A. De Rossi; E. D'andrea; D. Collavo
- Publisher
- John Wiley and Sons
- Year
- 1977
- Tongue
- French
- Weight
- 878 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
The genetics of late appearing MSV tumors showing a progressive growth pattern i n AKR mice was investigated. The late MSV tumor response in F, hybrids depended on the genetic background of the non-AKR parent. Within the 4-month observation period following virus injection, (CBA x AKR)F,, (DBA/ZxAKR)F,, and (NIH xAKR)F, developed progressing MSV tumors, which exhibited latency and growth behavior comparable t o that seen i n AKR mice. (BALBxAKR)F,, (BlxAKR)F,, and (BlOBRxAKR)F, mice did not show any late MSV tumors. In contrast to early regressing M-MSV tumors, whose development is independent of Fv-1 genotype, late MSV tumor progression i s largely a function of this gene, since all late tumors which appeared i n (BlOBR x AKR) x AKR were observed in Fv-ln homozygous mice. H-2k haplotype i s a further factor in the occurrence of late MSV tumors, at least i n (B6xAKR)xAKR mice. In crosses of AKR with Fv-1 compatible mica, tumor appearance was strongly associated with inheritance of AKR-MuLV, and MSV recovered from late tumors of f i r s t back-cross animals appeared t o be a new pseudotype with the endogenous AKR-MuLV. It is suggested that the host genetic control in both early and late MSV tumors i s exerted mainly on the helper component of the leukemia-sarcoma complex.