𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Efferent enhancement of a methylcholanthrene-induced Sarcoma transplantable in strain 13 guinea pigs

✍ Scribed by I. Berczi; H.-M. Tsay; A. H. Sehon

Publisher
John Wiley and Sons
Year
1976
Tongue
English
Weight
303 KB
Volume
6
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The immunobiology of an antigenic methylcholanthrene‐induced sarcoma (MC‐D) of inbred strain 13 guinea pigs has been investigated. The induction of concomitant immunity by growing MC‐D tumors was indicated by the suppression of small tumor inocula in the presence of a large tumor cell dose and by the regression of intradermal tumor nodules. Furthermore, it was demonstrated that this tumor was coated with antibody in vivo. Previous studies showed that MC‐D tumors were infiltrated with killer T cells which were capable of complete tumor destruction in vitro, but could never induce spontaneous regression in vivo. On the basis of all these facts, antibody‐mediated efferent enhancement is proposed to be the major escape mechanism of this tumor.

📜 SIMILAR VOLUMES

Influence of volume expansion on capilla
Influence of volume expansion on capillary transport in the gut of pichindé virus infected strain 13 guinea pigs
✍ Dr. Murray A. Katz; James F. Starr 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 474 KB

## Abstract Hydropenic strain 13 guinea pigs (GP13) injected with Pichindé virus show marked jejunal capillary disruption determined by a reduction in protein reflection coefficient (σ) [Katz and Starr, 1990]. These studies examined whether this is reversed by a 2% Ringer's expansion, and whether a

Some immunogenic and biochemical propert
Some immunogenic and biochemical properties of tumor-associated transplantation antigens (TATA) obtained in soluble form or solubilized from two methylcholanthrene-induced sarcomas, meth A and CI-4
✍ Michael J. Rogers; Lloyd W. Law 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 718 KB

## Abstract The subcellular distribution of the tumor‐associated transplantation antigens (TATAs) of two highly immunogenic methylcholanthrene‐induced sarcomas, Meth A and CI‐4, were compared. Most of the TATA of CI‐4 was found in the soluble fraction (cytosol) of the cell while the TATA from Meth