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Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

✍ Scribed by Obregon, Demian; Hou, Huayan; Deng, Juan; Giunta, Brian; Tian, Jun; Darlington, Donna; Shahaduzzaman, Md; Zhu, Yuyuan; Mori, Takashi; Mattson, Mark P.


Book ID
115486036
Publisher
Nature Publishing Group
Year
2012
Tongue
English
Weight
807 KB
Volume
3
Category
Article
ISSN
2041-1723

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BACE1 cleaves the amyloid precursor protein (APP) at the b-cleavage site (Met 671 -Asp 672 ) to initiate the generation of amyloid peptide Ab. BACE1 is also known to cleave APP at a much less well-characterized b 0 -cleavage site (Tyr 681 -Glu 682 ). We describe here the identification of a novel AP