𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Intracellular Generation of Amyloid β-Protein from Amyloid β-Protein Precursor Fragment by Direct Cleavage with β- and γ-Secretase

✍ Scribed by Tomomichi Iizuka; Mikio Shoji; Takeshi Kawarabayashi; Masahiro Sato; Takashi Kobayashi; Norihiro Tada; Kazuhiro Kasai; Etsuro Matsubara; Mitsunori Watanabe; Yasushi Tomidokoro; Shunsaku Hirai


Book ID
117979309
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
229 KB
Volume
218
Category
Article
ISSN
0006-291X

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Amyloid precursor protein mutation E682K
✍ Lujia Zhou; Nathalie Brouwers; Iryna Benilova; Annelies Vandersteen; Marc Mercke 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

BACE1 cleaves the amyloid precursor protein (APP) at the b-cleavage site (Met 671 -Asp 672 ) to initiate the generation of amyloid peptide Ab. BACE1 is also known to cleave APP at a much less well-characterized b 0 -cleavage site (Tyr 681 -Glu 682 ). We describe here the identification of a novel AP

Intracellular trafficking of the β-secre
✍ Pei Zhi; Cheryl Chia; Paul A. Gleeson 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 354 KB

The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the b-amyloid peptide (Ab) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Ab is derived from the proteolytic processing of t