The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the b-amyloid peptide (Ab) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Ab is derived from the proteolytic processing of t
Intracellular trafficking of the β-secretase and processing of amyloid precursor protein
✍ Scribed by Pei Zhi; Cheryl Chia; Paul A. Gleeson
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 139 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.570
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## Abstract The amyloid precursor protein (APP) is cleaved enzymatically by nonamyloidogenic and amyloidogenic pathways. α‐Secretase (α‐secretase), cleaves APP within the β‐amyloid (Aβ) sequence, resulting in the release of a secreted fragment of APP (αAPPs) and precluding Aβ generation. In this st