The molecular link between β- and γ-secretase activity on the amyloid β precursor protein
✍ Scribed by M. Tabaton; E. Tamagno
- Book ID
- 105758666
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 681 KB
- Volume
- 64
- Category
- Article
- ISSN
- 1420-682X
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📜 SIMILAR VOLUMES
The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the b-amyloid peptide (Ab) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Ab is derived from the proteolytic processing of t
BACE1 cleaves the amyloid precursor protein (APP) at the b-cleavage site (Met 671 -Asp 672 ) to initiate the generation of amyloid peptide Ab. BACE1 is also known to cleave APP at a much less well-characterized b 0 -cleavage site (Tyr 681 -Glu 682 ). We describe here the identification of a novel AP