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β-secretase processing of the Alzheimer’s amyloid protein precursor (APP)

✍ Scribed by Laura Marlow; Melissa Cain; Miguel A. Pappolla; Kumar Sambamurti

Book ID
111639656
Publisher
Humana Press Inc
Year
2003
Tongue
English
Weight
760 KB
Volume
20
Category
Article
ISSN
0895-8696

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The main component of the amyloid plaques found in the brains of those with Alzheimer's disease (AD) is a polymerized form of the b-amyloid peptide (Ab) and is considered to play a central role in the pathogenesis of this neurodegenerative disorder. Ab is derived from the proteolytic processing of t