Amyloid Precursor Protein Gene (APP) Variation in Late-Onset Alzheimer’s Disease
✍ Scribed by Ana Miar; Victoria Álvarez; Ana I. Corao; Marta Díaz; Belén Alonso; Carmen Martínez; María T. Calatayud; Manuel Menéndez; Germán Morís; Eliecer Coto
- Publisher
- Humana Press Inc
- Year
- 2011
- Tongue
- English
- Weight
- 123 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0895-8696
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## Abstract Linkage studies have suggested a susceptibility locus for late‐onset Alzheimer's disease (LOAD) on chromosome 21. A functional candidate gene in this region is the β‐amyloid precursor protein (APP) gene. Previously, coding mutations in APP have been associated with early onset Alzheimer
Alzheimer disease (AD) is a complex neurodegenerative disorder predisposed by multiple genetic factors. Mutations in amyloid beta precursor protein (APP) are known to be associated with autosomal dominant, early onset familial AD and possibly also late onset AD (LOAD). A number of genes encoding pro