Mutational analysis of the amyloid precu
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Hiroto Fujigasaki; Satoshi Naruse; Kiyotoshi Kaneko; Hideto Hirasawa; Shoji Tsuj
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Article
📅
1994
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Springer
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English
⚖ 310 KB
We sequenced the entire coding region of the amyloid precursor protein (APP) genes of 11 unrelated patients with Japanese familial Alzheimer's disease (FAD) in order to determine the exact frequency of known APP gene mutations and to search for novel mutations responsible for FAD. Three out of 11 (2