Solid-state nucleophilic aromatic substitution reaction of a carboxylic acid cocrystal

✍ Scribed by M.C. Etter; G.M. Frankenbach; J. Bernstein

• Book ID: 104232906
• Publisher: Elsevier Science
• Year: 1989
• Tongue: French
• Weight: 249 KB
• Volume: 30
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)80463-9

✦ Synopsis

A facile thermally activated aromatic nucleophilic substitution reaction is shown to take place in the solid state in cccrystals of 4-chloro-3,5dinitrobenzoic acid and 4-aminobenzoic acid. The cocrystals are also made in the solid state by grinding the two acids together at room temperature.