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Solid-Phase Synthesis of 2,4-Diaminopyrimidines via Lewis Acid-Mediated Aromatic Nucleophilic Substitution

โœ Scribed by Arvanitis, Elena A.; Chadha, Naresh; Pottorf, Richard S.; Player, Mark R.


Book ID
127299137
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
84 KB
Volume
6
Category
Article
ISSN
1520-4766

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โœ Seongkon Kim; Jane Yang; Frank DiNinno ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 191 KB

The boron trifluoride-etherate mediated cyclization of 2-arylthio-ketones la-h at ambient temperature gave 3-aryl-substituted benzothiophenes 2a-h in excellent yield. None of the rearranged 2-aryl-substituted benzothiophenes were observed.