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Preparation of 6-fluorobenzisothiazoles via a regioselective nucleophilic aromatic substitution reaction

✍ Scribed by David M. Fink; Joseph T. Strupczewski


Publisher
Elsevier Science
Year
1993
Tongue
French
Weight
232 KB
Volume
34
Category
Article
ISSN
0040-4039

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## Abstract Exclusive formation of 6‐aryloxy ethers **9** from an S~N~Ar reaction of methyl 2,6‐dichloronicotinate (**2**) with phenols **7** catalyzed by 1,4‐diazabicyclo[2.2.2]octane (DABCO) in the presence of stoichiometric triethylamine is described. The reaction proceeds __via__ the regioselec