Solid-Phase Total Synthesis of Cyclospor
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Soo Y. Ko; Roland M. Wenger
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Article
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1997
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John Wiley and Sons
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German
β 645 KB
Syntheses of cyclosporine analogues are reported wherein the peptide couplings were achieved in solid phase. The Wang resin was used as the solid support, and the peptide couplings commenced with the residue 11 of the cyclosporine skeleton. The couplings proceeded in a stepwide manner up to the res