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Solid-phase synthesis of Δ2-isoxazolines

✍ Scribed by Jie-Fei Cheng; Adnan M.M. Mjalli

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 186 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)10700-6

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✦ Synopsis

Solid-phase synthesis of A2-isoxazolines through a 1,3-dipolar cycioaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford A2-isoxazolines in good yields.

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