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Δ2-Isoxazolines from β,γ-unsaturated oximes

✍ Scribed by Michael D. Mosher; Laura G. Emmerich; Katherine S. Frost; Benjamin Anderson

Publisher
Journal of Heterocyclic Chemistry
Year
2006
Tongue
English
Weight
307 KB
Volume
43
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

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3,5‐Disubstituted Δ^2^‐isoxazolines can be prepared using the palladium‐mediated nucleometalation / methoxycarbonylation of β,γ‐unsaturated oximes. This novel route to this class of compounds is tolerant of a wide variety of functionality in the starting material, and provides a rapid route to highly functionalized isoxazolines.

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