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One pot solid phase synthesis of isoxazolines

โœ Scribed by B.B. Shankar; D.Y. Yang; S. Girton; A.K. Ganguly

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
111 KB
Volume
39
Category
Article
ISSN
0040-4039

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Solid-phase synthesis of ฮ”2-isoxazolines
Solid-phase synthesis of ฮ”2-isoxazolines
โœ Jie-Fei Cheng; Adnan M.M. Mjalli ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 186 KB

Solid-phase synthesis of A2-isoxazolines through a 1,3-dipolar cycioaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford A2-isoxazolines in good yields.