Solid-phase synthesis of A2-isoxazolines through a 1,3-dipolar cycioaddition of nitrile oxides is described. The aldoxime is oxidized with commercially available bleach to give the corresponding nitrile oxide, which reacts in situ with dipolarophiles to afford A2-isoxazolines in good yields.
✦ LIBER ✦
A new convenient synthesis of Δ2-isoxazolines
✍ Scribed by Stefan Kwiatkowski; Maria Langwald
- Publisher
- Springer Vienna
- Year
- 1986
- Tongue
- English
- Weight
- 133 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0026-9247
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