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Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

✍ Scribed by Wenteng Chen; Zhi Li; Lili Ou; Marc A. Giulianott; Richard A. Houghten; Yongping Yu

Book ID
104098843
Publisher
Elsevier Science
Year
2011
Tongue
French
Weight
243 KB
Volume
52
Category
Article
ISSN
0040-4039

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✦ Synopsis

The solid-phase synthesis of sultams from resin-bound amino acids is described. The sulfonylation of the resin-bound primary amines afforded the requisite secondary amines, after which the intramolecular Buchwald-Hartwig-type coupling forms the C-S bond. A final alkylation on the sulfonamides followed by cleavage provided the corresponding seven-membered sultams.

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