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Synthesis of a Solid-Phase Amino Imidazotriazine Library via Palladium Catalyzed Direct Arylation

โœ Scribed by Maechling, Simon; Good, James; Lindell, Stephen D.

Book ID
118124140
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
297 KB
Volume
12
Category
Article
ISSN
1520-4766

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โœ Yongping Yu; John M Ostresh; Richard A Houghten ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 100 KB

The solid-phase synthesis of indolines from resin-bound 2-bromophenylacetylated amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines that, following the palladium-catalyzed intramolecular cyclization and cleavage, provid