Solid-phase synthesis of heterocycles via palladium-catalyzed annulation
โ Scribed by Yao Wang; Tai-Nang Huang
- Book ID
- 104260386
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 201 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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๐ SIMILAR VOLUMES
The solid-phase synthesis of indolines from resin-bound 2-bromophenylacetylated amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines that, following the palladium-catalyzed intramolecular cyclization and cleavage, provid
Catalytic amounts of Pd(OAc)2 in the presence of c-Bu4NC1, OMF and an appropriate Et3N) cyclize nitrogen-containing o-lodoaryl alkenes to indoles, quinolines, isoquinolines and isoquTnolones in short reaction times, under mild temperatures, and in high yields. Transition metal reagents have proven h