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Solid-phase synthesis of indolines via palladium-catalyzed cyclization

โœ Scribed by Yongping Yu; John M Ostresh; Richard A Houghten

Book ID
104253204
Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
100 KB
Volume
44
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The solid-phase synthesis of indolines from resin-bound 2-bromophenylacetylated amino acids is described. The exhaustive reduction of solid-support bound amides with borane afforded the requisite secondary amines that, following the palladium-catalyzed intramolecular cyclization and cleavage, provided the corresponding disubstituted indolines.

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