Solid phase synthesis of peptidyl aldehydes from C-terminal thiazolidinyl peptides
β Scribed by Nathalie Galeotti; Matthieu Giraud; Patrick Jouin
- Book ID
- 110267874
- Publisher
- Springer Netherlands
- Year
- 1997
- Tongue
- English
- Weight
- 47 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1573-3149
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π SIMILAR VOLUMES
A new linker based on the dibenzosuberyl system was developed in order to synthesisΒ’ peptide Cterminal semicarbazones which can bΒ’ readily converted into peptide (7-terminal aldehydes. The method uses Fmoc-methodoiogy and proceeds with no loss of stereochemical integrity.
## Abstract Solidβphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for