An efficient method for the solid-phase synthesis of substituted guanidines is presented. A variety of alcohols react with resin-bound N,N'-bis(t-butoxycarbonyl)thiopseudourea under Mitsunobu conditions to give the corresponding alkylated thiopseudoureas. The guanidines are liberated from the resin
Solid-Phase Synthesis of N -Acyl- N ‘ -Alkyl/Aryl Disubstituted Guanidines
✍ Scribed by Ghosh, Ajit K.; Hol, Wim G. J.; Fan, Erkang
- Book ID
- 120650513
- Publisher
- American Chemical Society
- Year
- 2001
- Tongue
- English
- Weight
- 60 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3263
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📜 SIMILAR VOLUMES
A method for the solid-phase synthesis of disubstituted guanidines is reported. In this procedure, polymer-bound aryl or alkyl amines are converted to methyl isothioureas in three steps and treated with primary and secondary amines to form the disubstituted guanidine products.
## Abstract The reaction of 2,3,4‐tri‐O‐acetyl‐β‐D‐xylopyranosyl isothiocyanate (**1**) and 2‐amino‐4‐arylthiazoles (**2**) gave xylosylthioureas **3**. These thiourea derivatives reacted with alkyl/aryl amine in the presence of HgCl~2~ to give a new series of N‐alkyl/aryl‐N″‐(4‐arylthiazol‐2‐yl)‐N
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