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Synthesis of novel N-alkyl/aryl-N′-(4-arylthiazol-2-yl)-N″-xylosyl guanidines

✍ Scribed by Gen Li; Peng Wu; Ling Hua Cao

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
156 KB
Volume
18
Category
Article
ISSN
1042-7163

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✦ Synopsis

Abstract

The reaction of 2,3,4‐tri‐O‐acetyl‐β‐D‐xylopyranosyl isothiocyanate (1) and 2‐amino‐4‐arylthiazoles (2) gave xylosylthioureas 3. These thiourea derivatives reacted with alkyl/aryl amine in the presence of HgCl~2~ to give a new series of N‐alkyl/aryl‐N″‐(4‐arylthiazol‐2‐yl)‐N″‐xylosyl guanidines 4. Some of the synthesized guanidines were screened for their biological activity. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:688–694, 2007; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20379

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ChemInform Abstract: Synthesis of Novel N-Alkyl/Aryl-N′-(4-arylthiazol-2-yl)-N′′-xylosyl Guanidines.
✍ Gen Li; Peng Wu; Ling Hua Cao 📂 Article 📅 2008 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

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