Solid-Phase Synthesis of Mucin Glycopeptides
β Scribed by Mian Liu; David Live; George Barany
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 8 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Although no evidence of a-haloalkylsamarium formation has been obtained, a reactive cc-iodoethyl species is undoubtedly generated in an optically active form. In conclusion, the reaction of 1,l-diiodoalkanes with samarium(l1) diiodide in the presence of chiral aldehydes produces a-haloaikyl building
with K-selectride to afford the desired hydroxy compound 24. Desilylation of 24 with HF ' py gave the hydroxy oxime 25. The C=N bond of 25 was reduced with NaBH,CN providing the desired product 26 together with its C4 epimer.[131 Finally, chromatographically purified 26 was deprotected to the target