Solid-phase synthesis of hydroxy-acids leading to macrolactones
✍ Scribed by René Gagnon; Yves L Dory; Pierre Deslongchamps *
- Book ID
- 104210425
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 167 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
✦ Synopsis
A sequence of ®ve chemical steps on solid support yields hydroxy-acids in a very straightforward and ecient manner. The resulting compounds can be cyclized in solution phase by forming an ester bond to produce macrolactones.
📜 SIMILAR VOLUMES
The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylamin¢ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydr
Peptide nucleic acids (PNA) were synthesized by a modified Merrifield method using several improvements. Activation by O-[benzotriazol-1-yl]-1,1,3,3-tetramethyluronium hexafluorophosphate in combination with in situ neutralization of the resin allowed efficient coupling of all four Boc-protected PNA