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Highly efficient macrolactonization of ω-hydroxy acids using benzotriazole esters: synthesis of Sansalvamide A

✍ Scribed by Morales-Serna, José Antonio; Sánchez, Ericka; Velázquez, Ricardo; Bernal, Jorge; García-Ríos, Eréndira; Gaviño, Rubén; Negrón-Silva, Guillermo; Cárdenas, Jorge


Book ID
118218816
Publisher
Royal Society of Chemistry
Year
2010
Tongue
English
Weight
206 KB
Volume
8
Category
Article
ISSN
1477-0520

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A novel and efficient macrolactonization
✍ Isamu Shiina; Mari Kubota; Ryoutarou Ibuka 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 180 KB

A variety of lactones were prepared in high yields at room temperature from the corresponding v-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine. A similar reaction also occurs with triethylamine when using a catalytic amount of 4-(dimethyl