A novel and efficient macrolactonization
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Isamu Shiina; Mari Kubota; Ryoutarou Ibuka
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Article
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2002
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Elsevier Science
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French
⚖ 180 KB
A variety of lactones were prepared in high yields at room temperature from the corresponding v-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine. A similar reaction also occurs with triethylamine when using a catalytic amount of 4-(dimethyl