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A Novel and Efficient Macrolactonization of ω-Hydroxycarboxylic Acids Using 2-Methyl-6-nitrobenzoic Anhydride (MNBA).

✍ Scribed by Isamu Shiina; Mari Kubota; Ryoutarou Ibuka


Publisher
John Wiley and Sons
Year
2003
Weight
162 KB
Volume
34
Category
Article
ISSN
0931-7597

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A novel and efficient macrolactonization
✍ Isamu Shiina; Mari Kubota; Ryoutarou Ibuka 📂 Article 📅 2002 🏛 Elsevier Science 🌐 French ⚖ 180 KB

A variety of lactones were prepared in high yields at room temperature from the corresponding v-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride in the presence of 4-(dimethylamino)pyridine. A similar reaction also occurs with triethylamine when using a catalytic amount of 4-(dimethyl