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Solid phase synthesis of hydantoin library using a novel cyclization and traceless cleavage step

✍ Scribed by Sang Woong Kim; Sang Youl Ahn; Jong Sung Koh; Jin Ho Lee; Seonggu Ro; Hae Yeon Cho

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 165 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00986-6

No coin nor oath required. For personal study only.

✦ Synopsis

The variety of N, N-disubstituted hydantoin libraries were constructed using derivatives of amino acids, aromatic aldehydes, and isocyanates. The cyclization step of hydantoin was a novel, fast, and clean reaction and completed within five minutes to I hour with neat diisopropylamine. All library compounds were obtained in excellent yield with high purity even after 5 steps.

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