Solid phase synthesis of fumitremorgin, verruculogen and tryprostatin analogs based on a cyclization/cleavage strategy

Efficient Solid Phase Synthesis of Cleav

Efficient Solid Phase Synthesis of Cleavable Oligodeoxynucleotides Based on a Novel Strategy for the Synthesis of 5′-S-(4,4′-Dimethoxytrityl)-2′-deoxy-5′-thionucleoside Phosphoramidites

✍ Kerstin Jahn-Hofmann; Joachim W. Engels 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 German ⚖ 390 KB 👁 1 views

## Abstract The incorporation of a specific cleavage site into an oligodeoxynucleotide can be achieved by utilizing the four 5′‐__S__‐(4,4′‐dimethoxytrityl)‐2′‐deoxy‐5′‐thionucleoside 3′‐(2‐cyanoethyl diisopropylphosphoramidites) **5** and **15a**–**c** (__Fig. 1__). Based on the silver ion assiste