A new acetal resin valuable for the solid-phase synthesis of 1-oxacephamsvia a cyclization/cleavage step
✍ Scribed by Bartłomiej Furman; Rene´ Thu¨rmer; Zbigniew Kałuża; Wolfgang Voelter; Marek Chmielewski
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- French
- Weight
- 234 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0040-4039
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We have established that using an oxidation-Cope elimination cleavage protocol allows for the synthesis of N,N-disubstituted hydroxylamines from REM resin (polymer-bound benzyl acrylate). Michael addition of a secondary amine or addition of a primary amine followed by reductive alkylation provides p
The clean and efficient cleavage of N-benzyl linked tertiary amines from a solid support (e.g. 4) by treatment with ct-chloroethyl chloroformate (ACE-CI) / methanol to yield secondary amines 7 is described. This allows the solid-phase synthetic transformation of the secondary amine 2 into 7. When th
## Abstract Two novel solid‐phase organic tagging (SPOrT) resins were synthesized to facilitate the labeling of peptides and small organic compounds with a fluorescent probe. Both resins were obtained from the commercially available backbone amide linker (BAL) resin. Following the solid‐phase synth