Solid-phase synthesis of diverse tetrahydro-1,4-benzodiazepine-2-ones
โ Scribed by Gurdip Bhalay; Paul Blaney; Vanessa H. Palmer; Anthony D. Baxter
- Book ID
- 108385335
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- French
- Weight
- 179 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0040-4039
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A solid-phase synthesis ofpolysubstituted 1,5-benzodiazepin-2-ones is described. Resinbound 4-fluoro-3-nitrobanzoic acid was reacted with different ~amino acids, followed by nitro group reduction and formation of the seven-membered ring. Subsequent alkylations at N(5) and N(1) afforded the title com
Solid-phase synthesis of small-sized, non-peptidic molecules has emerged as an important drug discovery tool. 1 Synthesis of heterocyclic compounds on solidsupport, in particular, has been focused on because of their applications toward a variety of drug targets. 2 Among various heterocycles, quinaz
## Abstract An efficient solidโphase synthetic method for 2,3,4,5โTetrahydroโ1,4โbenzodiazepinโ2,5โdiones, having amine derivatives on the benzene ring, was developed. This method has been successfully applied to the synthesis of several spatially separated drugโlike and informationโrich smallโmole