Solid-phase synthesis of tetrahydro-1,4-benzodiazepin-2-one derivatives
โ Scribed by Jinfang Zhang; Wesley P. Goodloe; Boliang Lou; Hossain Saneii
- Book ID
- 110346916
- Publisher
- Springer
- Year
- 2000
- Tongue
- English
- Weight
- 203 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1381-1991
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## Abstract An efficient solidโphase synthetic method for 2,3,4,5โTetrahydroโ1,4โbenzodiazepinโ2,5โdiones, having amine derivatives on the benzene ring, was developed. This method has been successfully applied to the synthesis of several spatially separated drugโlike and informationโrich smallโmole
The solid phase synthesis of 1,4-benzothiazepin-5-one derivatives, resulting from the reaction of resin-bound protected cysteine with 2-fluoro-5-nitro-benzoic acid followed by a reductive aikylation and an intra molecular cyclization, is described.