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Solid-phase synthesis of C-terminal thio-linked glycopeptides

✍ Scribed by John P. Malkinson; Robert A. Falconer

Publisher: Elsevier Science
Year: 2002
Tongue: French
Weight: 122 KB
Volume: 43
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(02)02419-x

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✦ Synopsis

A solid-phase Mitsunobu reaction between a resin-bound 1-thiosugar and an N-Fmoc protected amino alcohol was successfully employed for thio-linked glycopeptide synthesis. Facile cleavage and deprotection in one step afforded the target glycopeptide in good yield and purity.

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