Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry

✍ Scribed by Xiangyang Wu; Yu Yuan; Xuechen Li; Samuel J. Danishefsky

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 333 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.06.005

✦ Synopsis

The reaction of oligosaccharide isonitriles with peptide thioacids in the presence of bulky thiophenol as activator to provide N-linked glycopeptides at room temperature is described.