✦ LIBER ✦

Solid-phase synthesis of amino amides and peptide amides with unnatural side chains

✍ Scribed by William L Scott; Francisca Delgado; Karen Lobb; Richard S Pottorf; Martin J O'Donnell

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 86 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)00090-9

No coin nor oath required. For personal study only.

✦ Synopsis

Unnatural amino amides and peptide amides can be synthesized, using solid-phase chemistry, from glycine attached directly (or through an intervening peptide sequence) to a Rink resin. The glycine is converted to an activated benzophenone imine derivative, followed by C-alkylation and hydrolysis. This sequence provides a mild, high yielding route to Rink resin-bound racemic, unnatural, amino amides and di-and tripeptide amides. Cleavage with trifluoroacetic acid provides the final amide products in good yield and purity.

📜 SIMILAR VOLUMES

Solid-phase synthesis of C-terminal pept

Solid-phase synthesis of C-terminal peptide amides from N-tetrachlorophthaloyl protected amino acids

✍ Esther Cros; Marta Planas; Xavier Mejı́as; Eduard Bardajı́ 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 67 KB

A new strategy for solid-phase synthesis of C-terminal peptide amides based on the use of N-tetrachlorophthaloyl protected amino acids with acid-labile side-chain protection is described.

A new approach to the solid-phase peptid

A new approach to the solid-phase peptide synthesis of peptide alkyl-amides and esters

✍ Ernesto Nicolás; Javier Clemente; Margarita Perelló; Fernando Albericio; Enrique 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 338 KB

Solid phase synthesis of α-hydroxyglycin

Solid phase synthesis of α-hydroxyglycine extended peptides -biological precursors of peptide amides

✍ Angus R. Brown; Robert Ramage 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 237 KB

Solid Phase Synthesis of Peptides with C

Solid Phase Synthesis of Peptides with Carboxyl-Terminal Amides—Thyrotropin-Releasing Factor (TRF)

✍ Dr. Erhard Gross; Dr. Kosaku Noda; Dr. Bruce Nisula 📂 Article 📅 1973 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB 👁 2 views

Synthesis of cyclic peptide hybrids with

Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains

✍ Marta Planas; Eduard Bardajı́; George Barany * 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 102 KB

Head-to-tail cyclic peptides with hybrid side-chains have been synthesized by solid-phase assembly of the linear sequences, followed by PyAOP/HOAt/DIEA-mediated cyclization either while resin-bound or, after cleavage, in solution.

Solid-Phase and Solution-Phase Syntheses

Solid-Phase and Solution-Phase Syntheses of Oligomeric Guanidines Bearing Peptide Side Chains.

✍ Zhongsheng Zhang; Erkang Fan 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 8 KB 👁 1 views