Synthesis of cyclic peptide hybrids with amino acid and nucleobase side-chains
✍ Scribed by Marta Planas; Eduard Bardajı́; George Barany *
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- French
- Weight
- 102 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
Head-to-tail cyclic peptides with hybrid side-chains have been synthesized by solid-phase assembly of the linear sequences, followed by PyAOP/HOAt/DIEA-mediated cyclization either while resin-bound or, after cleavage, in solution.
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Unnatural amino amides and peptide amides can be synthesized, using solid-phase chemistry, from glycine attached directly (or through an intervening peptide sequence) to a Rink resin. The glycine is converted to an activated benzophenone imine derivative, followed by C-alkylation and hydrolysis. Thi
Although the conformations of two linked peptide units both with glycyl and alanyl residues have been extensively studied,'-$ no systematic investigation of the energies of conformations of two linked peptide units with side chains beyond the CB atom and a comparison with the available crystallograp
Four new N-Fmoc cc-amino acids carrying a nucleobase in the side chain were prepared starting from L-glutamic acid. N-Boc-glutamic acid ct benzyl ester underwent a radical decarboxylation in the presence of CBrCl3 to give the corresponding 2-amino-4-bromobutanoic acid derivative. The four nucleobase