✦ LIBER ✦

Solid phase synthesis of 2-substituted benzofurans via the palladium-catalysed heteroannulation of acetylenes

✍ Scribed by Daniele Fancelli; Maria Chiara Fagnola; Dino Severino; Angelo Bedeschi

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 279 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00301-8

No coin nor oath required. For personal study only.

✦ Synopsis

The copper/palladium-promoted heteroannulation of terminal acetylenic compounds in the presence of resin bound ortho-hydroxy aryl iodides is described. The process produces 2-substituted benzofuran derivatives in good yield and high purity.

📜 SIMILAR VOLUMES

Synthesis of Trisubstituted Indoles on t

Synthesis of Trisubstituted Indoles on the Solid Phase via Palladium-Mediated Heteroannulation of Internal Alkynes

✍ Han-Cheng Zhang; Kimberly K. Brumfield; Bruce E. Maryanoff 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 621 KB

PsfMiunr-medistd haaoennufstion ofinterred tdkynes withresin-bound o-iodomdm ""e dwivadves 4 or 5a pmided diverse trisubstituted indoles 6 in goodyields. The fecile reactionof trirnethylsilylalkynes sfforded resin-bound precursors usefrdforobtainirrg other 2-substituted indolederivadves, suchas 12.

Solution and solid-phase synthesis of hy

Solution and solid-phase synthesis of hydroxamic acids via palladium catalysed cascade reactions

✍ Ronald Grigg; Jeremy P. Major; Fionna M. Martin; Mark Whittaker 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 163 KB

Synthesis of 2-hetaryl substituted indol

Synthesis of 2-hetaryl substituted indoles via palladium-catalysed reductive N-heterocyclisation

✍ S. Tollari; S. Cenini; A. Rossi; G. Palmisano 📂 Article 📅 1998 🏛 Elsevier Science 🌐 English ⚖ 107 KB

Solid-phase synthesis of indoles using t

Solid-phase synthesis of indoles using the palladium-catalysed coupling of alkynes with iodoaniline derivatives

✍ Maria Chiara Fagnola; Ilaria Candiani; Giuseppina Visentin; Walter Cabri; Franco 📂 Article 📅 1997 🏛 Elsevier Science 🌐 French ⚖ 266 KB

Solid-phase synthesis of peptides using

Solid-phase synthesis of peptides using allylic anchoring groups 2. Palladium-catalysed cleavage of Fmoc-protected peptides

✍ Paul Lloyd-Williams; Ahmed Merzouk; François Guibé; Fernando Albericio; Ernest G 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 384 KB

High yklds for the cleavage reaction of Fmoc-protected peptide segments fmn an allylic handle may be obtained using tributyltin hydride in the jmsence of (ph3P)PdQ in a 1:l mixture of DMF/DCM. Altematively tbe cleavage reacdon may be carried out using NMA as nuclecpbile in a 2:2:1 mixture of DMSOfl'

Efficient synthesis of 3-substituted 2-a

Efficient synthesis of 3-substituted 2-arylindoles via Suzuki coupling reactions on the solid phase

✍ Han-Cheng Zhang; Hong Ye; Kimberly B White; Bruce E Maryanoff 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 96 KB

2-Aryl-3-alkylindoles were prepared on solid phase via palladium-mediated heteroannulation of 1-alkyl-2-(trimethylsilyl)acetylene with amide resin-bound o-iodoaniline 1, followed by transformation of trimethylsilyl to iodide and then Suzuki coupling reactions. Traceless synthesis of symmetrical and