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Synthesis of Trisubstituted Indoles on the Solid Phase via Palladium-Mediated Heteroannulation of Internal Alkynes

โœ Scribed by Han-Cheng Zhang; Kimberly K. Brumfield; Bruce E. Maryanoff

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
621 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

PsfMiunr-medistd haaoennufstion ofinterred tdkynes withresin-bound o-iodomdm ""e dwivadves 4 or 5a pmided diverse trisubstituted indoles 6 in goodyields. The fecile reactionof trirnethylsilylalkynes sfforded resin-bound precursors usefrdforobtainirrg other 2-substituted indolederivadves, suchas 12.

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