Synthesis of 1,2,3-trisubstituted pyrrolo[3,2-c]quinolines via palladium-catalyzed heteroannulation with internal alkynes

✍ Scribed by Seung Kyu Kang; Sang Sun Park; Sung Soo Kim; Joong-Kwon Choi; Eul Kgun Yum

• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 210 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00753-4

✦ Synopsis

Various 1,2,

quinolines were synthesized by palladium-catalyzed heteroannulation of 4-amino-3-iodoquinoline derivatives and internal alkynes. The 1,2,3-trisubstituted pyrrolo[3,2-c]quinolines could be further transformed by desilylation, debenzylation, or substitution.